Shape Memory Polymer Thesis

Shape Memory Polymer Thesis-56
Ink patterned on the surface of the SMP sheet absorbs thermal energy from the IR light, which produces localized heating.

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These substrates and scaffolds were applied in vitro and in vivo to demonstrate their potential as platforms to study cell mechanobiology and as functional tissue engineered constructs.

The first part of this dissertation describes the fabrication and application of an SMP bilayer system capable of forming nano-scale wrinkles under cytocompatible conditions.

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The proposed modeling framework was used to obtain a fundamental understanding of the thermo-mechanical behavior of SMPs and the impact of the material behavior on hinged self-folding.

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These predictions indicated how the thermal and mechanical conditions during pre-strain significantly affect the shrinking and folding response of the SMP.As a result, recent efforts have focused on developing complex synthetic materials that can mimic the dynamic in vivo cell environment.In this work, shape memory polymers (SMPs) were employed to develop dynamic 2D substrates and 3D scaffolds that undergo programmed changes in shape under cell compatible conditions.Furthermore, deployable SMP foams showed potential for use as deployable cell-based therapies to facilitate bone repair, as expanding foams were able to support osteogenic differentiation of attached stem cells.This work demonstrates the potential of SMPs to be employed as dynamic materials to study cell-material interactions in dynamic environments and to aid in the development of functional tissue engineered constructs. Google(); req('single_work'); $('.js-splash-single-step-signup-download-button').one('click', function(e){ req_and_ready('single_work', function() ); new c. D.)--North Carolina State University, 2017.; Publication Number: AAT 10610763; ISBN: 9781369856460; Source: Dissertation Abstracts International, Volume: 78-10(E), Section: B.; 212 p.By continuing to use this site, you consent to the use of cookies.We use cookies to offer you a better experience, personalize content, tailor advertising, provide social media features, and better understand the use of our services.The potential of SMP foams for use as synthetic bone substitutes was demonstrated in a mouse segmental defect model, where expanding foams were deployed intraoperatively to fill and conform to a critical size defect.Stiff SMP foams were able to maintain defect stability in a load-bearing application and integrated with the native bone after 12 weeks.


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