The consistently poor performance in fast-frequency variability and error rates may be due to difficulties in sustained attention that fluctuate on a trial-to-trial basis. In a fixed sequence version of the task, children were required to withhold their response to a predictably occurring no-go target (3) in a 1–9 digit sequence; in the random version the sequence was unpredictable.Keywords: Sustained attention; Response time; Fast Fourier transform; Frontal cortex; Endophenotype © 2006 Elsevier Ltd. Neuropsychlogia 45 (2007) 2234-2245 Dissociation in performance of children with ADHD and high-functioning autism on a task of sustained attention Katherine A. The ADHD group showed clear deficits in response inhibition and sustained attention, through higher errors of commission and omission on both SART versions.On the Fixed SART, a normal number of errors was made, however when the stimuli were randomised, the HFA group made as many commission errors as the ADHD group.
The consistently poor performance in fast-frequency variability and error rates may be due to difficulties in sustained attention that fluctuate on a trial-to-trial basis. In a fixed sequence version of the task, children were required to withhold their response to a predictably occurring no-go target (3) in a 1–9 digit sequence; in the random version the sequence was unpredictable.
A fixed-sequence Sustained Attention to Response Task (SART) was given to 29 control, 39 unimpaired and 24 impaired- ADHD children (impairment defined by the number of commission errors).
The response time data were analysed using the Fast Fourier Transform, to define the fast-frequency and slow-frequency contributions to overall response variability.
One aspect of the attention deficit in ADHD includes a subtle inattention to left space, resembling that seen after right cerebral hemisphere damage.
Since left-sided inattention in ADHD may resolve when treated with MPH, we asked whether left-sided inattention in ADHD was related to DAT1 genotype and the therapeutic efficacy of MPH.
The HFA group showed no sustained attention deficits, through a normal number of omission errors on both SART versions.
The HFA group showed dissociation in response inhibition performance, as indexed by commission errors.This section of information contains the research and abstracts from published papers from the Institute of Neuroscience at Trinity College Dublin and University College Dublin.It may be a useful source of information for students, medical professionals and those involved in education.The higher error rates of the impaired-ADHD group did not become differentially greater over the length of the task. We probed executive function in these disorders using a sustained attention task with a validated brain-behaviour basis.The progressive slowing in mean RT over the course of the task may relate to a deficit in arousal in the impaired-ADHD group. Twenty-three children with ADHD, 21 children with high-functioning autism (HFA) and 18 control children were tested on the Sustained Attention to Response Task (SART).MPH may be most efficacious in this group because it ameliorates a DAT1-mediated hypodopaminergic state.Keywords: DAT1; dopamine; ADHD; methylphenidate; attention; genetics American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 136B (2005) :81–86 DRD4 Gene Variants and Sustained Attention in Attention Deficit Hyperactivity Disorder (ADHD): Effects of Associated Alleles at the VNTR and _521 SNP Mark A.A within-family control design determined whether asymmetry indices predicted biased transmission of 10-repeat parental DAT1 alleles and/or response to MPH.It was found that left-sided inattention predicted transmission of the 10-repeat allele from parents to probands and was associated with the severity of ADHD symptomatology.Although no immediate cure is in sight for it, a better understanding of ADHD through the research programmes gives us all more information on the role of the brain and effective treatments for the disorder. Robertson a School of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland b Schools of Psychiatry and Genetics and Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland c Cognitive Neurophysiology Laboratory, Nathan S.Neuropsychologia 45 (2007), 630-638 Response variability in Attention Deficit Hyperactivity Disorder: Evidence for neuropsychological heterogeneity Katherine A. Kline Institute, Orangeburg, NY 10962, United States d Cognitive Neuroscience Laboratory, School of Behavioural Science, University of Melbourne, Australia Abstract Response time (RT) variability is a common finding in ADHD research.