Pharmacy Case Studies

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As a result, the neuron will be less likely to go through depolarisation, which ultimately results in neuronal inhibition.

As a result, the neuron will be less likely to go through depolarisation, which ultimately results in neuronal inhibition.

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diazepam, prazepam, clorazepate) are eliminated relatively slowly, others are metabolised rather rapidly (e. In anticonvulsant and anti-anxiety treatment, stable blood levels of the drug are pursued so that compounds with long elimination half-lives of parent drug or active metabolites are of advantage.

Metabolism of benzodiazepines, such as oxazepam and lorazepam, is not impaired in the elderly and in those with liver dysfunction.

Benzodiazepines have five major clinical indications: This five-fold clinical activity is possessed, to a greater or lesser extent, by all benzo­diazepines in current clinical use.

The properties of benzodiazepines make them ideally useful for managing anxiety (e.g.

diazepam, chlordiazepoxide, lorazepam); insomnia (e.g. diazepam, temazepam, nitrazepam, loprazolam, ­flurazepam, lormetazepam); epilepsy (e.g.

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