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The implication of oxytocin in social development and affiliative behaviors has been ascertained and findings from clinical trials in children with ASD showed encouraging results especially in social cognition.
Drugs commonly used to treat mitochondrial diseases such as L-carnitine, complex B vitamins, antioxidants etc.
have been found to improve ASD symptoms in some studies, but results are still conflicting and more research is needed.
Among these, it has to be outlined that in a large multisite controlled study memantine was not shown to improve core and associated symptoms in ASD and the open phase of the trial was in fact suspended.
Similarly, cholinesterase inhibitors did not show substantial modifications in ASD core symptoms and their use is still not warranted.
New ASD treatments are emerging and deserve to be mentioned.
Autism Treatment Research Paper Writing Lent Research Papers
A number of novel medications have been used off-label in various studies, including drugs approved for Alzheimer’s disease, as reviewed by Rossignol and Frye (3).The last part of the book is dedicated to basic studies highlighting the importance of investigating mouse models to unravel the molecular mechanisms underlying ASD pathogenesis.Two review articles, respectively by Cellot and Cherubini (13) and Giovedí and coworkers (14), address the role of GABAergic neurotransmission and synaptic vesicle proteins in the pathogenesis of ASD, strengthening the notion of ASD as a “synaptic neuropathology”.Tordjman S, Davlantis K, Georgieff N, Speranza M, Xavier J, Botbol M, et al.Autism as a disorder of biological and behavioral rhythms: towards new therapeutic perspectives. doi:10.3389/fped.2015.00001 Cross Ref Full Text | Google Scholar 9. Reducing maladaptive behaviors in preschool aged children with autism spectrum disorder using the early start denver model. doi:10.3389/fped.2014.00040 Pubmed Abstract | Pubmed Full Text | Cross Ref Full Text | Google Scholar 10. Predictors of outcomes in autism early intervention: why don’t we know more? doi:10.3389/fped.2014.00058 Pubmed Abstract | Pubmed Full Text | Cross Ref Full Text | Google Scholar 11.Among the bothersome ASD symptoms that need to be addressed, auditory hypersensitivities may be tackled by means of novel techniques such as the listening protocol projects, as proposed by Porges (11).Poor reciprocal social communication is a hallmark characteristic of ASD and is under intense investigation for treatment; Corbett and colleagues report a novel theatre intervention that combines interaction of trained peers with patients to facilitate the performance-based theatrical treatment (12).Potential therapeutic benefits of melatonin in the recovery of circadian rhythms have been demonstrated in a growing number of studies in ASD.Developmental behavioral interventions that emphasize synchrony (in some cases combined with melatonin) seem to provide substantial improvement in ASD, as reviewed by Tordjman (8) and reported by Fulton (9).These preliminary clinical trials point to additional research in larger samples.Notably, modifications of neural pathways of ASD have been observed after behavioral developmental interventions through the evaluation by functional neuroimaging and electroencephalography, providing evidence of a dynamic neural substrate susceptible of functional changes.